INJECTABLE HYBRID LAPONITE/ALGINATE HYDROGELS FOR SUSTAINED RELEASE OF METHYLENE BLUE

摘要：

The incorporation of biocompatible Laponite (LP) into alginate hydrogels greatly increases the drug encapsulation efficiency of methylene blue (MB). By raising the LP content from 0 to 0.5 wt.％, the half-release time (t1/2) of MB in oven-dried gels increases from ~2 h to ~10 h, while t1/2 in vacuum-dried gels slightly changes from ~1 h to ~2 h. Increasing LP content together with drying modes can induce the MB release mechanism from a diffusion-controlled release into a swelling-controlled one.

关键词： laponite alginate injectable hybrid hydrogels drug delivery release mechanisms

作者: Yulin Li Jose Luis Santos Dina Maciel Helena Tomas Joao Rodrigues

作者单位: Centro de Quimica da Madeira, Universidade da Madeira, Campus da Penteada 9000-390 Funchal,Portugal

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 169-171

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）