POLY(L-GLUTAMIC ACID)-BASED STAR-BLOCK COPOLYMERS AS pH-RESPONSIVE RELEASE SYSTEMS

摘要：

Synthesis of star-block copolymers based on poly(L-glutamic acid), their encapsulation, as well as pH-responsive release properties are described. The star-block copolymers are composed of a hyperbranched polyethyleneimine (PEI) core, a poly(L-glutamic acid) inner shell, and a poly(ethylene glycol) (PEG) outer shell. A cationic model dye crystal violet and model anticancer drug adriamycin hydrochloride can be efficiently entrapped by the synthesized star-block copolymers at physiological pH as a result of electrostatic interactions. The loaded drugs in the star-block copolymer have a high temporal stability, but display remarkably accelerated release upon a gradual decrease in the solution pH.

关键词： poly(l-glutamic acid) star-block copolymer drug delivery controlled release

作者: Yunsong Yan Lihui Liao Daoiun Liu

作者单位: Medical College, Shantou University, Xinling Road 22, Shantou 515041, China

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 178-180

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）