CONTROLLED ACID HYDROLYSIS AND ACETYLATION OF GLUCOMANNANS AS DRUG CARRIERS WITH DESIGNED PHARMACOKINETIC BEHAVIORS

摘要：

Glucomannans with designed molecular weights and acetylation substitution degrees have been prepared by controlled acid hydrolysis and acetylation of Bletillan, obtained from Bletilla Striata. The molecular weights and other structural features were determined by MALS, HPGPC, IR, NMR methods etc. The pharmacokinetic behavior of three samples (BT40, 70 and 110) was studied by intravenous administration in normal rabbits. Plasma elimination half times of these samples were determined to be 5.63, 9.56 and 13.61 hours, respectively. These results indicated that the pharmacokinetic parameters of the glucomannans could be tuned by selection of suitable molecular weights, which is important when these materials are being considered as novel drug delivery carriers.

关键词： glucomannan bletilla striata acid hydrolysis acetylation pharmacokinetics

作者: Jiangyun Liu Yan Zhang Yin Yin Fang Peng Peilie Cai Shilin Yang

作者单位: Department of Medicinal Chemistry, School of Pharmacy, Medical College of Soochow University,Suzhou Department of Medicinal Chemistry, School of Pharmacy, Medical College of Soochow University,Suzhou

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 181-183

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）