THE SYNERGISTIC EFFECT OF HERCEPTIN AND DOCETAXEL IN POLYLACTIDE-D-α-TOCOPHERYL POLYETHYLENE GLYCOL SUCCINATE (PLA-TPGS) NANOPARTICLES

摘要：

This work investigated and presented the synergistic effect of Herceptin and docetaxel in PLA-TPGS nanoparticles (NPs) which are effective vehicles of docetaxel delivery. The anticancer effect of docetaxel was amplified in the NPs with Herceptin which also induces targeted delivery of docetaxel. In vitro cytotoxicity studies were conducted on SK.-BR-3 human breast cancer cells to demonstrate the synergistic effect of Herceptin and docetaxel. The essential docetaxel concentration can be reduced to even 100-fold with the combination of Herceptin.

关键词： herceptin docetaxel synergistic effect nanoparticle drug delivery

作者: Yutao Liu Si-Shen Feng

作者单位: Department of Chemical & Biomolecular Engineering , National University of Singapore, Block E5, 02-1 Department of Chemical & Biomolecular Engineering , National University of Singapore, Block E5, 02-1

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 187-189

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）