pH-RESPONSIVE POLYMERIC-CARGO ENCAPSULATED MAGNETIC NANOPARTICLES FOR SELECTIVE RELEASE AND IMAGING

摘要：

A novel water-soluble, pH-responsive copolymer was successfully synthesized and used as polymeric-cargo to deliver hydrophobic paramagnetic nanoparticles into cells. The as-synthesized amphiphilic copolymer nano-cargo has excellent biocompatibility and degradation properties. The hydrophobic side-chain of the copolymer can insert into oleic acid with the hydrophilic part on the surface to form water-soluble nanocomposites. Furthermore, this composite can also easily load hydrophobic drugs via hydrophobic interaction. Due to the degradation process of the polymer shell under weak acidic condition, the polymeric-cargo can unpack magnetic nanoparticles and drugs, resulting in MRI signal switching and drug release, respectively. Our approach can achieve outstanding dual functions, tumor diagnosis and therapy.

关键词： pH-sensitive degradable copolymers magnetic resonance imaging drug delivery

作者: Dongyun Chen Najun Li Xuewei Xia Qingfeng Xu Jianfeng Ge Yonggang Li Jianmei Lu Honewei Gu

作者单位: Key Laboratory of Organic Synthesis of Jiangsu Province, Key Laboratory of Absorbent Materials and T Department of Radiology, the First Affiliated Hospital of Soochow University, Soochow University,Suz Key Laboratory of Organic Synthesis of Jiangsu Province, Key Laboratory of Absorbent Materials and T

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 193-195

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）