A NOVEL DUAL STIMULI-RESPONSIVE DRUG CARRIER BIOMATERIAL BASED ON BSA/PVP POLYMERS

摘要：

A novel drug carrier with dual response to temperature and pH, based on bovine serum albumin and poly(vinyl pyrrolidone), was synthesized via in-situ polymerization and subsequent self-assembly in aqueous solution. Its structure and morphology were characterized by FT-IR, TEM, DLS and UV-Vis spectra. The size of the microspheres was about 200 -400 nm. The microspheres had a core-shell structure and carried a negative charge in aqueous solution. Their response to temperature and pH was investigated. The carriers showed a continuous release of entrapped doxorubicin hydrochloride over approximately 50 h. The results of data fitting showed that the drug release behavior agreed with the Higuchi equation.

关键词： BSA-based polymers dual stimuli-responsive biomaterials drug carrier controlled release poly (vinyl pyrrolidone)

作者: Chong-Wu Mao Rong-Min Wang Hui-Fang Zhang Yu-Feng He Ji-De Tao Xiao-Chun Ying

作者单位: Key Laboratory of Eco-Environment-Related Polymer Materials of Ministry of Education, Key Laboratory of Polymer Materials of Gansu Province, College of Chemistry & Chemical Engineering,Northwest Normal University, Lanzhou 730070, China

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 196-198

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）