PREPARATION AND IN VITRO RELEASE OF SPRAY-DRIED CHITOSAN MICROSPHERES FOR LEVOFLOXACIN DELIVERY
Levofloxacin (LOF) was incorporated into chitosan microspheres for controlled release. The microspheres were prepared by spray-drying technology combined with glutaraldehyde cross-linking. The drug-loaded microspheres showed a golf ball-like particals with a size distribution between 0.5 and 2 μrn. The encapsulation efficiency of LOF within microspheres was up to 88.78％. The in vitro release behavior of LOF-CS microspheres was investigated and showed two distinct stages. The present investigation provides a scope for using levofloxacin-loaded chitosan microspheres for combatting ocular surface infections.
chitosan levofloxacin spray-dry controlled release
Jiayu Cai Yin Zhang Wennan Du Kaihui Nan
Eye Hospital, Wenzhou Medical College, Wenzhou 325027, China
国际会议
The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)
苏州
英文
199-201
2010-09-14（万方平台首次上网日期，不代表论文的发表时间）