HYDROGEL-BASED DRUG CARRIERS FOR CONTROLLED RELEASE OF HYDROPHOBIC DRUGS AND PROTEINS

摘要：

Hydrogel-based drag carriers have been developed for the controlled release of hydrophobic drugs and proteins. In the first example, a hydrogel was designed for the controlled release of hydrophobic drugs. For this gel, maleimide-modified dextran (dex-mal) was used as the backbone of an in situ forming hydrogel functionalized with β-cyclodextrins (CD). In the second example the release of proteins from the hydrogel was controlled by light. In this case Dex-mal was functionalized with azobenzene (AB) and CD to construct a supramolecular hydrogel based on the inclusion complex between trans-AB and CD, which was used as a photo-switchable crosslinker to control the release of physically entrapped proteins.

关键词： cyclodextrin dextran hydrogel hydrophobic drug protein

作者: Ke Peng Itsuro Tomatsu Alexander Kros

作者单位: Leiden Institute of Chemistry, Leiden University, P.O.Box 9502, 2300 RA Leiden, The Netherlands

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 205-207

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）