THERMOSENSITTVE, BIOCOMPATIBLE AND ANTIFOULING NANOGELS PREPARED VIA AQUEOUS RAFT DISPERSION POLYMERIZATION FOR TARGETED DRUG DELIVERY
Smart and biocompatible nanogels prepared via aqueous dispersion polymerization have significant advantages in nanomedicine. Herein, a RAFT-mediated dispersion polymerization approach was developed for the preparation of novel type of core-shell nanogels mainly composed of polymeric or oligomeric ethylene glycol. Macromolecular chain transfer agents (Macro-CTA) based on linear PEG and brush-type poly(oligo(ethylene glycol methacrylate)) (pOEGMA) were use for the dispersion (co)polymerization of OEGMA. These nanogels with narrow size distribution exhibited tunable LCST, nontoxicity and excellent colloidal stability in the presence of high concentrations of NaCl (1.5 M), BSA (1％) and serum (100％), rendering these nanogels promising candidates for drug delivery applications.
RAFT dispersion polymerization nanogels biocompatible polymers thermosensitive polymers drug delivery
Wenqing Shen Yanli Chang Haifang Wang Guangyao Liu Aoneng Cao Zeshene An
Institute of Nanochemistry and Nanobiology, College of Environmental and Chemical Engineering,Shanghai University, Shanghai 200444, China
国际会议
The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)
苏州
英文
211-213
2010-09-14（万方平台首次上网日期，不代表论文的发表时间）