DEGRADABLE WATER SOLUBLE HYPERBRANCHED POLYMERS FOR DRUG DELIVERY
Hyperbranched polymers (HBP) with terminal thiol groups and internal hydroxyl groups were prepared from 1,4-dithiothreitol and glyceryl triacrylate. Hydrophilic polymer PEG (550) and cancer drugs (such as camptothecin (CPT) and methotrexate (MTX)) were grafted to the thiol groups and the hydroxyl groups, respectively, forming amphiphilic hyperbranched polymer-drug conjugates, PEG-HPB-CPT, PEG-HBP-MTX and PEG-HBP-S-S-MTX. These conjugates existed as unimicelles in water at low concentration, and self-assembled into multimolecular micelles at high concentration. The MTT experiments showed that the PEG-HBP showed no cytotoxicity and the conjugates had slightly lower cytotosity than the corresponding free drugs, and the subcellular localization of conjugates was observed by confocal fluorescent microscopy, suggesting that the micelles could quickly get into lysosomes in 2 h.
hyperbranched polymers drug delivery conjugate
Xingping Wang Jianbin Tang Meihua Sui Xinping Wang Jinxia Xu Youqing Shen
Center for Bionanoengineering, Department of Chemical and Biological Engineering , Zhejiang Universi Center for Bionanoengineering, Department of Chemical and Biological Engineering , Zhejiang Universi Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Education Ministry, Dep
国际会议
The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)
苏州
英文
214-216
2010-09-14（万方平台首次上网日期，不代表论文的发表时间）