NANOGATED VESSEL BASED ON POLYPSEUDOROTAXANE-CAPPED MESOPOROUS SILICA VIA A HIGHLY ACID-LABILE BENZOIC-IMINE LINKER

摘要：

pH-responsive nanogated vessels based on polypseudorotaxane-capped mesoporous silica via a highly acid-labile benzoic-imine linker is prepared and used for controlled drug delivery. The benzoic-imine bond hydrolyzes under very slightly acidic conditions (e.g. extracellular pH of tumor tissue 6.8) whereas it is stable at neutral and basic pH. By changing the environmental pH from physiological pH to slightly acidic pH, i.e., 7.4 to 6.8, faster drug release can be clearly seen. Preliminary experiments showed that tumor specificity could be gained from the inclusion of the benzoic-imine linker.

关键词： mesoporous silica polypseudorotaxane acid-labile controlled release

作者: Yaohua Gao Rujiang Ma Yingli An Linqi Shi

作者单位: Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 223-225

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）