REDUCTION-RESPONSIVE SHELL-SHEDDABLE BIODEGRADABLE MICELLES FOR INTRACELLULAR DOXORUBICIN DELIVERY

摘要：

Novel reduction-responsive micelles based on a diblock copolymer dextran-SS-poly (ε-caprolactone) (Dex-SS-PCL) were designed and applied for triggered intracellular release of doxorubicin (DOX). These micelles, formed via the dialysis method, were stable in aqueous solutions, but rapidly aggregated in response to 10 mM dithiothreitol (DTT). In vitro release studies revealed quick and quantitative release of DOX under an intracellular-mimicking reductive environment. DOX-loaded Dex-SS-PCL micelles displayed significantly faster release of DOX inside cells than the reduction-insensitive counterparts, resulting in markedly enhanced drug efficacy.

关键词： reduction-responsive shell-sheddable micelles biodegradable drug delivery.

作者: Huanli Sun Bingnan Guo Ru Cheng Fenghua Meng Haiyan Liu Zhiyuan Zhong

作者单位: Biomedical Polymers Laboratory and Jiangsu Key Laboratory of Organic Chemistry , College of Chemistr Laboratory of Cellular and Molecular Tumor Immunology, Tang Chung Ying Blood Research Center,Medical

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 229-231

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）