NOVEL REDUCTION-SENSITIVE MICELLES FOR TRIGGERED INTRACELLULAR DRUG RELEASE

摘要：

Novel reduction-sensitive micelles were developed based on poly(ethylene oxide)-b-poly(N-methacryloyl-N-(t-butyloxycarbonyl)cystamine) (PEO-b-PMABC) diblock copolymers and applied for triggered intracellular drug release. PEO-b-PMABC micelles are stable at normal physiologic condition but readily cleaved into free copolymers under reducing environment. In vitro release of doxorubicin (DOX) and cell experiments showed that drug-loaded PEO-b-PMABC micelles accomplished much faster drug release under reducing conditions and higher anticancer efficacy as compared to the control without reduction-sensitivity, indicating great potential of PE0-b-PMABC micelles for efficient intracellular drug delivery.

关键词： drug delivery micelle RAFT polymerization reduction-sensitive

作者: Peijian Sun Danhua Zhou Zhihua Gan

作者单位: CAS Key Laboratory of Engineering Plastics, Institute of Chemistry, Chinese Academy of Sciences,Beij CAS Key Laboratory of Engineering Plastics, Institute of Chemistry, Chinese Academy of Sciences,Beij

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 232-234

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）