NONTOXIC GEMINI CATIONIC BIODEGRADABLE POLYURETHANE DRUG CARRIERS: SYNTHESIS, SELF-ASSEMBLY AND IN VITRO CYTOTOXICITY

摘要：

A series of multiblock gemini poly(ε-caprolactone urethane)s were developed, and self-assembled into micellar structures with sizes below 100 nm, positive surface charges, extremely low critical micelle concentrations and enhanced drug loading capacity. Moreover, the paclitaxel incorporated polyurethane micelles showed significant cytotoxicity on Lewis lung carcinoma cells, while the blank micelles have good biocompatibility even as the concentration is up to 0.1 mg/mL. These gemini polyurethane micelles hold great promise as biodegradable carriers for drug and gene delivery.

关键词： Gemini biodegradable polyurethane self-assembly cytotoxicity drug delivery.

作者: Mingming Ding Xueling He Lijuan Zhou Jiehua Li Hong Tan Xiaoting Fu Qiang Fu

作者单位: College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, S Laboratory Animal Center of Sichuan University, Chengdu 610041, China

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 235-237

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）