β-CYCLODEXTRIN-BASED BIODEGRADABLE DENDR1MERS FOR DRUG DELIVERY

摘要：

Novel polyester dendrimers using β-cyclodextrin (β-CO) as the core and their conjugates with PEG and anticancer drug methotrexate (MTX) were synthesized and characterized by 1H NMR and GPC. The conjugates with the solubilizing group PEG formed nano-micelles in aqueous solution with sizes from 50 to 80 nm. The dendrimer-MTX conjugates showed effective activity against breast cancer (BC) in vitro with an IC50 of 0.068 ng/mL, and the subcellular localization of the conjugates was observed by confocal fluorescent microscopy, indicating that the conjugates mainly localized in lysosomes.

关键词： β-cyclodextran dendrimer biodegradable drug delivery methotrexate

作者: Jianbin Tang Xingping Wang Xinping Wang Meihua Sui Weiwei Mao Youqing Shen

作者单位: Department of Chemical & Biological Engineering, and Center of Bionanoengineering, Zhejiang Universi Department of Chemistry, Key Laboratory of Advanced Textile Materials and Manufacturing Technology o

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 238-240

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）