PREPARATION AND CHARACTERIZATION OF CAMPTOTHECIN (CPT)-LOADED FOLATE-CONJUGATED DEXTRAN NANOPARTICLES FOR TUMOR-TARGETED DRUG DELIVERY USING SUPERCRITICAL ANTISOLVENT METHOD

摘要：

Camptothecin (CPT)-loaded folate-conjugated dextran nanoparticles (FA-DEXNPs-CPT) for tumor-targeted drug delivery have been prepared using supercritical antisolvent (SAS) method. Results under optimum conditions for mean particle size, zeta potential, entrapment efficiency, loading efficiency and in vitro drug release of uniform and spherical FA-DEXNPs-CPT were found to be 182.21±5.2 nm, -28.84±2.66 mV, 62.13％, 36.12％ and 14.79％ in 180 h, respectively. FT-IR, DSC and XRD results indicated the CPT was entrapped within the folate-conjugated dextran nanoparticles.

关键词： camptothecin (CPT) folate dextran supercritical antisolvent tumor-targeted delivery

作者: Xiuhua Zhao Dan Wang Yuangang Zu Ru Jiang Dongmei Zhao Yong Li Baishi Zu Zhiqiang Sun Qi Zhang

作者单位: Key Laboratory of Forest Plant Ecology, Northeast Forestry University, Ministry of Education,P.O.Box 332, Harbin, Heilongjiang 150040, China

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 241-243

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）