NOVEL pH-SENSITIVE ZWITTERIONIC POLY(AMINO ACID) DERIVATIVES FOR DRUG DELIVERY

摘要：

New biodegradable and pH-sensitive zwitterionic poly(aspartic acid) derivatives were synthesized by conjugation of amines, such as N-(3-aminopropyl)morpholine(AMP), methyl L-histidine dihydrochloride(His-OME), dimethylpropylenediamine(DMAP), and ethylenediamine(EDA). Depending on the pKa of the grafted amine, the isoelectric point (IEP) of the polymer can be effectively adjusted. The solution behavior of these polymers has been studied by turbidity, size distribution and zeta potential measurements. Initial work shows that polymer with a molar ratio of 0.33 of DMAP has a high buffering capacity and pH sensitivity.

关键词： zwitterionic polymer poly(aspartic acid) ph-sensitive drug delivery

作者: Xiaojuan Wang Guolin Wu Tao He Yong Wang Yinong Wang Yunge Fan Hui Gao Jianbiao Ma

作者单位: Key Laboratory of Functional Polymer Materials (Ministry of Education), Institute of Polymer Chemist School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300191,China

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 246-248

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）