BIOCOMPATIBLE HYDROGELS BASED ON CHITOSAN AND POLY(P-DIOXANONE)

摘要：

The tri-block copolymer (PPDOEG) of poly(p-dioxanone) and poly (ethylene glycol) (PEG) with the aldehyde terminal group (PPDOEG-CHO) was synthesized by the oxidization of PPDOEG in the presence of acetic anhydride. The chitosan-based hydrogels were prepared by using PPDOEG-CHO as a macromolecular crosslinker. The obtained hydrogels were used as Ibuprofen carrier. It was found that the release of Ibuprofen from the hydrogels was sustained for 50 h. The cytotoxicity results revealed that these hydrogels had good biocompatibility with L929 cells.

关键词： chitosan poly(p-dioxanone) poly(ethylene glycol) ibuprofen cell cytotoxicity

作者: Yanli Zhai Xiuli Wang Xiaoyu Li Yuzhong Wang

作者单位: Center for Degradable and Flame-Retardant Polymeric Materials, College of Chemistry, Sichuan Univers State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University,Chengdu

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 249-251

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）