IN VITRO AND IN VIVO EVALUATION OF IBUPROFEN-PAEONOL CONJUGATE

摘要：

Ibuprofen is one of widely used non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment of rheumatoid arthritis. However, the potential of causing adverse effects limits its further clinical application. Therefore, a novel ibuprofen-paeonol conjugate (IPC) was synthesized by esterification to improve the therapeutic efficacy and decrease the gastrointestinal (GI) tract irritation of ibuprofen. The systemic evaluations of IPC were carried out including pharmaceutical characterization, pharmacodynamics and GI irritation of IPC. The results of the systemic evaluation indicated that IPC had an enhanced anti-inflammatory activity and showed fewer side effects as compared to ibuprofen.

关键词： ibuprofen paeonol conjugate in vitro and in vivo evaluation

作者: Dan Wu Guizhen Ao Qingri Cao Dawei Chen Jinghao Cui

作者单位: Department of Pharmaceutics, School of Pharmacy, Medical College of Soochow University, Suzhou 215123, China

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 258-260

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）