SYNTHESIS OF AZOBENZENE FUNCTIONALIZED DENDRITIC BLOCK COPOLYMER BASED ON HYPERBRANCHED PDMAEMA AND INVESTIGATION OF ITS DRUG RELEASE PROPERTIES

摘要：

An azobenzene functionalized amphiphilic dendritic block copolymer based on hyperbranched PDMAEMA was synthesized by the combination of AGET ATRP and self-condensing vinyl polymerization techniques. The degree of branching of hyperbranched PDMAEMA can be controlled by the initial molar ratio of inimer and monomer. The kinetic and chain extension investigation showed that the polymerization was living. Using chlorambucil as the model drug, the drug loaded block copolymer showed controlled chlorambucil release which was sensitive to both pH and light.

关键词： stimuli-responsive polymer hyperbranched polymer living free radical polymerization drug release

作者: Minying Xing Weihua Guo Zhenping Cheng Zhengbiao Zhang Jian Zhu Xiulin Zhu

作者单位: Key Lab.of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 270-272

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）