PHOTO-CROSSLINKED BIODEGRADABLE MICELLES FOR PACLITAXEL RELEASE

摘要：

Crosslinked biodegradable micelles were developed based on poly (ethylene glycol)-poly (acryloyl carbonate)-polylactide (PEG-PAC-PLA) triblock copolymer. The facile combination of PEG-PAC-PLA and folate-PEG-PLA yielded stable micelles with varying folate densities. The crosslinked micelles had sizes ranging from 85 to 140 run with a low PDI of 0.05-0.14. MTT assay using KB cells revealed that these crosslinked micelles were not cytotoxic. These micelles showed high loading efficiencies for paclitaxel (PTX) and minimal drug release upon dilution. The enhanced drug stability combined with active targeting may effectively improve tumor-targetability of biodegradable micelles.

关键词： photo-crosslinked micelle biodegradable drug release anticancer drug

作者: Juan Xiong Fenghua Meng Zhiyuan Zhong

作者单位: Biomedical Polymers Laboratory and Jiangsu Key Laboratory of Organic Chemistry, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 273-275

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）