ANTITUMOR ACTIVITY OF DRUG LOADED GLYCYRRHETINIC ACID MODIFIED ALGINATE NANOPARTICLES ON MICE BEARING ORTHOTOPIC LIVER TUMOR

摘要：

Doxorubicin loaded glycyrrhetinic acid modified alginate nanoparticles (DOX/GA-ALG NPs) were prepared for liver targeting drug delivery. The biodistribution and antitumor activity were examined and the results showed that DOX/GA-ALG NPs mainly accumulated in the liver and exhibited more effective suppression in tumor growth of mice bearing orthotopic liver tumor as compared with DOX-HCl. Histological examination confirmed tumor necrosis and that liver cells were not affected after DOX/GA-ALG NPs administration. These results revealed the promising potential of DOX/GA-ALG NPs as liver targeting drug delivery system.

关键词： glycyrrhetinic acid alginate biodistribution antitumor orthotopic liver tumor

作者: Chuangnian Zhang Yukun Wu Tong Liu Yue Zhao Xiuhua Wang Wei Wang Zhi Yuan

作者单位: Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistr College of Chemistry, Chemical Engineering and Material Science, Soochow University, Suzhou 215123,

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 285-287

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）