LIGHT AND ELECTRON MICROSCOPY CHARACTERIZATION OF A COLLAGEN-LIPOSOMES-ENTRAPPED CHONDROITIN SULPHATE COMPOSITE AS INTRA-ARTICULAR DRUG DELIVERY SYSTEM

摘要：

A new collagen-liposomes-entrapped chondroitin sulphate composite has been prepared for use as intra-articular drug delivery system. In the presence of collagen, liposomes with encapsulated chondroitin sulphate were entrapped within the fibril network. Immunohistochemical analysis of collagen-liposomes-entrapped chondroitin sulphate porous composite showed that liposomes adhere firmly to the surface of the collagen bundles.

关键词： liposomes chondroitin sulphate collagen articular drug delivery

作者: Otilia Zarnescu Lucia Moldovan Mihaela Trif Magda Moisei Oana Craciunescu

作者单位: Department of Animal Biology, Faculty of Biology, University of Bucharest, Splaiul Independentei 91- Department of Cellular and Molecular Biology, National Institute of Research and Development for Bio Institute of Biochemistry, Splaiul Independentei 296, Bucharest 060031, Romania

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 288-290

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）