FORMATION AND CONTROLLED RELEASE OF THE INCLUSION COMPLEX OF WATER SOLUBLE MODEL DRUG NEUTRAL RED WITH β-CYCLODEXTRIN GRAFTED SODIUM ALGINATE

摘要：

A biodegradable and biocompatible polymer,β-cyclodextrin grafted sodium alginate (β-CD-g-ALG) was synthesized. The inclusion formation and drug release of water soluble model drug neutral red (NR) with β -CD-g-ALG were studied in comparison with β-cyclodextrin (β-CD). The results showed that the inclusion constants of NR with β-CD (NR-β-CD) and β-CD-g-ALG (NR-β-CD-g-ALG) were 575 L/mol and 6.65×104 L/mol, respectively. The NR loading content, release time and amount released from NR-β-CD-g-ALG were 23, 1.3, 30 times as high as those from NR-β-CD, respectively. These excellent inclusion and release abilities due to some kind of synergistic effect of β-CD and alginate polymer chain could be significant for the controlled delivery of water soluble drugs.

关键词： β-cyclodextrin sodium alginate neutral red inclusion complex controlled release

作者: Shiping Zhang Xuemei Qiao Bihuang Hu Yongkuan Gong

作者单位: Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education,Colle Ocean College, Hainan University, Haikou 570228, China

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 294-296

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）