PREPARATION AND PROPERTIES OF MULTI-RESPONSIVE SEMI-IPN HYDROGEL MODIFIED MAGNETIC NANOPARTICLES AS DRUG CARRIER

摘要：

Multi-responsive semi-interpenetrating network hydrogel modified Fe3O4 magnetic nanoparticles were designed and synthesized using a two-step aqueous polymerization method, where Fe3O4 nanoparticles served as the core and semi-IPN hydrogel consisting of poly-N-isopropylacrylamide (PNIPAM, thermoresponsive) and polyacrylic acid (PAA, pH-responsive) was used as the shell. Results showed that the average diameter of the modified magnetic particles was about 200-600 nm, and the saturation magnetization was about 6.42 emu/g. The modified magnetic particles were sensitive to temperature and pH, which shows potential application in the field of intelligent controlled drug delivery.

关键词： Fe3O4 nanoparticle thermoresponsive pH-responsive controlled delivery

作者: Fen He Yi Zhang Ji Li Siwei Liu Zhenguo Chi Jiarui Xu

作者单位: Key Laboratory of the Ministry of Education for Polymer Composite and Functional Materials, Key Laboratory of Designed Synthesis and Application of Polymer Material, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 300-302

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）