DRUG CARRIERS BASED ON CYCLODEXTRIN INCLUSION COMPLEXES FOR THE CONTROLLED RELEASE OF HYDROPHOBIC DRUGS

摘要：

A water-soluble β-CD derivative -carbonyl-β-CD was synthesized and characterized by Fourier transform infrared spectroscopy (FT-IR) and mass spectroscopy (MS). Drug release was studied by Ultraviolet-Vis (UV-Vis) spectroscopy using carbonyl-β-CD as drug carrier, water-insoluble benzoin as target drug, and water-soluble amantadine as competing agent. The formation of a benzoin-carbonyl-β-cyclodextrin inclusion complex greatly improved the solubility and bioavailability of benzoin. The target drug benzoin was released from the benzoin-carbonyl-β-cyclodextrin inclusion complex by adding the competing agent amantadine to the solution. The results showed that carbonyl-β-CD is an excellent drug carrier, and can be applied in controlled release of drugs.

关键词： carbonyl-β-cyclodextrin benzoin inclusion complex competing agent amantadine

作者: Leyan Xiong Longzhen Zheng Kui Han Qiang Liu Yindi Li Wen Lin Jian Xia Wei Wang

作者单位: Department of Chemistry and Chemical Engineering, East China Jiao Tong University, Nanchang 330013, China

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 303-305

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）