COMPOSITE MICELLES CONSISTING OF PACLITAXEL-AND FOLIC ACID-CARRYING COPOLYMERS FOR TREATMENT OF LEWIS LUNG CANCER

摘要：

Paclitaxel (PTX)-conjugated copolymer, poly(ethylene glycol)-b-poly(L-lactide-co-2-methyl-2-carboxyl-propylene carbonate/PTX), and folk acid (FA)-conjugated copolymer, poly(ethylene glycol)-b-poly(L-lactide-co-2,2-dihydroxylmethyl-propylene carbonate/FA), have been synthesized and used for preparing composite micelles. Dual agent micelles have a spherical shape and an average diameter of about 58 nm. In vivo studies in a mouse model of Lewis lung cancer demonstrated a better therapeutic efficacy of composite micelles delivering both drug agent -PTX and targeting agent -FA than micelles only delivering PTX.

关键词： composite micelles targeting therapy paclitaxel folic acid lewis lung cancer

作者: Yonghui Zheng Yanhui Wan Xiangfu Song Xiuli Hu Shi Liu Xiabin Jing

作者单位: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry,Chin The First Hospital,Changchun 130021, China School of Public Health, Jilin University, Changchun 130021, China

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 306-308

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）