DENDRIMER-MODIFIED GOLD NANORODS AS EFFICIENT CONTROLLED GENE DELIVERY SYSTEM UNDER NEAR-INFRARED LIGHT IRRADIATION
Gold nanorods coated with polyamidoamine dendrimer can deliver brcaal-shRNA into MCF-7 cells with high efficiency, and realized targeted silencing of brcaalgene in MCF-7 cells. Specifically, gold nanorods have a controllable absorbance band at ~850 nm, which can be used to monitor their position in cancer cells and also can be used to enhance expression of brcaal-shRNA in MCF-7 cells and its inhibition effects on growth of MCF-7 cells under local infrared irradiation. MTT analysis showed that dendrimer-coated gold nanorods exhibited very low cytotoxicity. In conclusion, dendrimer-modified gold nanorods maybe one kind of good gene delivery system for cancer therapy, and have potential applications in future tumor therapy.
gold nanorods polyamidoamine dendrimer brcaal gene RNA interference near-infrared light irradiation
Daxiang Cui Peng Huang Chuilei Zhang Cengiz S.Ozkan Bifeng Pan Ping Xu
Department of Bio-Nano-Science and Engineering, National Key Laboratory of Nano/Micro Fabrication Te Centerfor Nanoscience & Engineering, University of California, Riverside, CA 92521,USA
国际会议
The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)
苏州
英文
336-338
2010-09-14（万方平台首次上网日期，不代表论文的发表时间）