PREPARATION OF NOVEL BIODEGRADABLE TERNARY COPOLYMERS MPEG-b-P(MCC-g-OEI) AND THEIR GENE DELIVERY

摘要：

A series of biodegradable mPEG-b-P(MCC-g-OEI) (PPO) copolymers were synthesized by grafting oligoethylenimines (OEIs) with different molecular weights to rnPEG-b-PMCC. PPO600 and PPO1800 could efficiently condense DNA into nanosized particles (100-140 nm) with positive charges. The in vitro gene transfection showed that the PPO copolymers had great potential as non-viral gene vectors, especially the PPO 1800, which exhibited higher gene transfection efficiency than PEI25k in absence of serum in CHO cells.

关键词： polycarbonates derivative oligoethylenimine mPEG gene delivery

作者: Xuan Dong Lei Chen Huayu Tian Jie Chen Xuesi Chen Yen Wei Atsushi Marayama Tae Gwan Park

作者单位: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Department of Chemistry and School of Biomedical Engineering, Drexel University, Philadelphia,PA 191 Institute for Materials Chemistry and Engineering, Kyushu University, Fukuoka 812-8581, Japan Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-7

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 339-341

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）