SUPRAMOLECULAR ASSEMBLY OF CYCLODEXTRIN-BASED NANOSPHERES FOR GENE DELIVERY

摘要：

Polymeric hollow nanospheres were prepared by self-assembly of rod-coil complexes, in which the rod-like segments were formed by inclusion complexes of β-cyclodextrins (β-CDs) and poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) diamines. Nanospheres encapsulating DNA or polyethylenimine/DNA (PEI/DNA) were synthesized and characterized in terms of their supramolecular structures, DNA binding and condensation ability, cytotoxicity, and in vitro gene transfection efficiency in HepG2 cells.

关键词： hollow nanospheres cyclodextrin supramolecular gene transfection

作者: Min-min Fan Xi-Zhang Bang-jing Li Xun Sun Sheng Zhang

作者单位: State Key Laboratory of Polymer Materials Engineering (Sichuan University), Polymer Research Institu Chengdu Institute of Biology, Chinese Academy of Science, Chengdu 610041, China West China School of Pharmacy, Sichuan University, Chengdu 610041, China

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 342-344

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）