ONE-POT PREPARATION OF POLYETHLYENIMINE/SILICA HYBRIDE NANOPARTICLES AS SERUM-RESISTANT GENE DELIVERY VECTORS:TRANSFECTION AND INTRACELLULAR TRAFFICKING

摘要：

Novel organic/inorganic hybrid silica nanoparticles with size below 200 nm were one-pot prepared via Michael addition between 3-methacryloxypropyltrimethoxysilane (MPTMS) and polyethylenimine (PEI), followed by hydrolysis and polycondensation of silaxanes. In vitro transfection assay demonstrated that the transfection efficiencies of the nanoparticles were superior to PEI (25 kDa) in the presence of 10％ serum.

关键词： silica nanoparticles PEI gene delivery serum-resistant

作者: Wen-Tao He Ya-Nan Xue Wen-Ming Liu Shi-Wen Huang Ren-Xi Zhuo

作者单位: Key Laboratory of Biomedical Polymers of Ministry of Education Department of Chemistry, Wuhan University, Wuhan 430072, China

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 351-353

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）