GLIA/ISCHEMIA TISSUE DUAL SPECIFIC GENE EXPRESSION VECTOR FOR GLIOBLASTOMA GENE THERAPY
For glia/hypoxia dual specific gene expression, a dual specific expression vector was developed. pEpo-NI2-SV-Luc or pEpo-NI2-SV-was constructed with the nestin intron 2 (NI2)-SV40 promoter and erythropoietin (Epo) enhancer for glia cell and hypoxia specific gene expression. Gene expression by pEpo-NI2-SV-Luc was higher than pSV-Luc in glioblastoma cells under hypoxia. pEpo-NI2-SV-TK was constructed and transfected into C6 cells. The growth of the pEpo-NI2-SV-TK transfected cells was significantly suppressed in the presence of GCV.
gene regulation hypoxia glioblastoma gene therapy
Hyun Ah Kim Ji Hwan Park Su Hee Cho Jiyoung Lee Minhyung Lee
Department of Bioengineering, Hanyang University, 17 Haengdang-dong, Seongdong-gu, Seoul 133-791, Korea
国际会议
The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)
苏州
英文
354-356
2010-09-14（万方平台首次上网日期，不代表论文的发表时间）