CNGR CONJUGATED POLY(LACTICACID)-POLY(ETHYLENE GLYCOL) NANOPARTICLES FOR TARGETED GENE DELIVERY

摘要：

Cyclic asparagines-glycine-arginine (cNGR) peptide was used to target gene loaded poly(lactic acid)-poly(ethylene glycol) nanoparticles (PLA-PEG NPs) to human umbilical vein endothelial cells (HUVEC). cNGR modified gene loaded PLA-PEG nanoparticles (cNGR-PLA-PEG NPs) could effectively condense DNA into small-sized complexes (< 200 nm) with positive charge (~10 mV) using a novel cationic surfactant, 6-lauroxyhexyl lysinate (LHLN). cNGR-PLA-PEG NPs could be internalized into HUVEC by caveolae-mediated endocytosis with higher gene transfection efficiency and lower cytotoxicity than PLA-PEG NPs.

关键词： gene therapy active targeting poly(lactic acid)-poly(ethylene glycol) asparagines-glycine-arginine

作者: Chunxi Liu Wangyang Yu Zhijin Chen Jian Zhang Na Zhang

作者单位: Department of Pharmaceutics, School of Pharmaceutical Science, Shandong University, 44 West culture Road, Jinan 250012, China

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 372-374

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）