SYNTHESIS AND PHYSICOCHEMICAL EVALUATION OF MALEIC ANHYDRIDE-GRAFTED-POLY(D,L-LACTIDE-CO-GLYCOLIDE) AS FUNCTIONAL STENT COATING FOR LOCALIZED GENE DELIVERY

摘要：

The present study describes a novel strategy to covalently immobilize genes onto inert PLGA films via -CONH-cross-links. PLGA with functional carboxylic acid groups was synthesized using free-radical grafting maleic anhydride (MA) groups onto the polymer backbone. Cationic PEI/DNA complexes were successfully immobilized onto the functional PLGA films and characterized by ATR-FTIR and SEM analysis. We conclude that robust PLGA with functional carboxylic groups is a suitable platform for localized gene delivery.

关键词： localized gene delivery covalent immobilization PLGA maleic anhydride graft

作者: Guilei Ma Mei Yu Mingming Chen Cunxian Song

作者单位: The Tianjin Key Laboratory of Biomaterials, Institute of Biomedical Engineering, Peking Union Medical College & Chinese Academy of Medical Sciences, Tianjin 300192, China

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 384-386

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）