GLUCOSE-RESPONSIVE MICROHYDROGELS BASED ON METHACRYLATE MODIFIED DEXTRAN/CONCANAVALIN A FOR INSULIN DELIVERY

摘要：

Glucose-responsive microhydrogels based on methacrylate derivatives of dextran and concanavalin A have been prepared and used for self-regulated insulin delivery. Insulin release from these microhydrogels was in response to different glucose concentrations in the medium and the glucose sensitivity was reversible. The released insulin was proved to remain active without destroying the tertiary structure. The degree of substitution (DS) of the dextran methacrylate derivative had effect on the glucose sensitivity of the microhydrogels.

关键词： glucose-responsive microhydrogel concanavalin A insulin delivery

作者: Ruixue Yin Zi Tong Dongzhi Yang JunNie

作者单位: State Key Laboratory of Chemical Resource Engineering, Key Lab of Beijing City on Preparation and Pr State Key Laboratory of Chemical Resource Engineering, Key Lab of Beijing City on Preparation and Pr

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 387-389

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）