OLIGOARGININE-MODIFIED CHITOSAN FOR siRNA DELIVERY
Small interfering RNA (siRNA) has been widely investigated as a potential therapeutic for treatment of various diseases. However, naked siRNA is rapidly degraded by nucleases, showing poor cellular uptake and low transfection efficiency. Chitosan-based nanoparticles have been extensively exploited as a gene delivery carrier due to low toxicity and positively charged amino groups of chitosan. In this study, we synthesized 9R-modified chitosan and used it to form stable nanoparticles in the presence of siRNA. Various physicochemical properties of the nanoparticles, including size, surface charge, and complex forming ability, were investigated.
chitosan arginine siRNA gene delivery
Soveon Park Sang Kyung Lee Kuen Yong Lee
Department of Bioengineering, Hanyang University, Seoul 133-791, Korea
国际会议
The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)
苏州
英文
390-391
2010-09-14（万方平台首次上网日期，不代表论文的发表时间）