SYNTHESIS OF BIODEGRADABLE CATIONIC TRIBLOCK COPOLYMER mPEG-PCL-PLL FOR siRNA DELIVERY

摘要：

Amino-terminated methoxy poly(ethylene glycol)-b-poly(e-caprolactone) (mPEG-PCL-NH2) was synthesized by azidizing the end OH group of mPEG-PCL and by subsequent hydrogenation of the azido group. It was used to initiate ring-opening polymerization of ε-CBz (L-lysine)-N-carboxyanhydride to obtain cationic triblock copolymer methoxy poly(ethylene glycol)-b-poly(ε-caprolactone)-b-poly(L-lysine) (mPEG-PCL-PLL). The copolymer could self-assemble directly in water into nanoscale micelles with a hydrophobic core and a cationic corona. Therefore, they can further complex with anionic siRNA for possible application in gene delivery.

关键词： Amino-tenninated PEG-PCL NCA ring-opening polymerization siRNA delivery

作者: Ruogu Qi Xiuli Hu Lesan Yan Xuesi Chen Yubin Huang Xiabin Jing

作者单位: State key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry,Chin State key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry,Chin

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 395-397

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）