DELIVERY OF PROTEIN DRUGS USING NANOPARTICLES SELF-ASSEMBLED FROM DEXTRAN SULFATE AND QUATERNIZED CHITOSAN

摘要：

Polysaccharides based nanoparticles were prepared by self-assembly of quaternized chitosan and dextran sulfate via simple ionic-gelation. Quaternized groups were introduced in chitosan to increase its water solubility and to make the nanoparticles which are sensitive in a broader pH range which remain more stable at physiological pH and from which the loss of protein drugs caused by the gastric cavity can be decreased. Cell uptake study demonstrated that NPs can be internalized into Caco-2 cells, and cell viability appeared not to be affected which suggested that nanoparticles had good biocompatibility.

关键词： dextran sulfate quaternized chitosan protein drugs oral delivery biocompatibility

作者: Shujun Shu Xinge Zhang Zhongming Wu Zhen Wang Chaoxing Li

作者单位: Key Laboratory of Functional Polymer Materials Ministry of Education, Institute of Polymer Chemistry Metabolic Diseases Hospital, Tianjin Medical University, Tianjin 300070, China

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 401-403

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）