SYNTHESIS OF BIOREDUCIBLE AND ACID LABILE POLY(AMIDO AMINE)S VTA MICHAEL-ADDITION REACTIONS AND THEIR APPLICATION IN GENE DELIVERY

摘要：

Reducible poly(amido amine)s (HPAAs) with acid labile groups have been prepared via Michael addition polymerization. These PAAs are very sensitive to reducing agents such as dithiotreitol (DTT) and glutathione (GSH), and sensitive to pH. The polymers show good condensing property for DNA and good gene transfection efficiency.

关键词： poly(amido amine)s bioreducible polymer acid labile polymer

作者: Zhiqiang Yu Junjie Yan Yezi You

作者单位: CAS key Lab of Soft Matter Chemistry, and Department of Polymer Science and Engineering,University of Science and Technology of China, Hefei 230026, China

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 419-421

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）