NOVEL POLY(L-LYSINE) PARTICLES FOR GENE DELIVERY

摘要：

In this work, we designed replica particles based on poly(L-lysine) (PLL) polymers crosslinked via a homobifunctional linker to support coadsorption of a plasmid DNA and a peptide hormone for concurrent transfection and induction of a cellular function. PLL replica particles (PLLrp) were prepared. Based on this PLLrp gene delivery system, we simultaneously evaluated the melanin stimulation and gene expression by fluorescence microscopy. Our data suggest that the PLLrp is a promising vector for gene therapy and hormone stimulation.

关键词： mesoporous silica poly(L-lysine) replica particles gene delivery hormone stimulation

作者: Xin Zhang Guang-Hui Ma Zhi-Guo Su Nadia Benkirane-Jessel

作者单位: National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academ Institut National de la Sante et de la Recherche Medicate, INSERM, Unite 977, Faculte de Medecine,11

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 425-427

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）