AN EFFICIENT pH SENSITIVE ORAL INSULIN DELIVERY SYSTEM ENHANCED BY DEOXYCHOLIC ACID

摘要：

A permeation enhancer, positively charged deoxycholyl-hyperbranched oligoethylenimine (DCO), was prepared and used to form complexes with negatively charged insulin based on electrostatic interaction. DCO/insulin complexes can be loaded into poly (L-glutamic acid) (PGA) microspheres by the oil-in-oil (O/O) emulsion and solvent evaporation technique. Because of the specific pH sensitive properties of PGA, these insulin encapsulated microspheres are stable in the stomach and disaggregate in the small intestine, and the bioavailability of oral insulin administration will be improved due to DCOs permeation enhancement function.

关键词： insulin oral delivery permeation enhancer pH sensitive poly(L-glutamic acid)

作者: Li Zhao Jianxun Ding Pan He Chunsheng Xiao Zhaohui Tang Xiuli Zhuang Xuesi Chen

作者单位: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 428-430

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）