IMPROVEMENT OF GENE DELIVERY OF PDMAEMA BY INCORPORATING A HYPERBRANCHED POLYMER CORE

摘要：

A novel strategy to improve the transfection efficiency as well as lower the cytotoxicity for PDMAEMA polycationic vectors has been developed. The cytotoxicity decreases and the transfection efficiency increases significantly through the incorporation of a hydrophobic hyperbranched PEHO core into PDMAEMA. The effectiveness of the hyperbranched architecture for the gene transfection was further proved by comparing the PEHO-star-PDMAEMAs vector with a linear, molecular weight-analogous PEHO core as the control.

关键词： hyperbranched gene transfection cytotoxicity PDMAEMA

作者: Haixing Cheng Hui Deng Linzhu Zhou Yue Su Songrui Yu Xinyuan Zhu Yongfeng Zhou Deyue Yan

作者单位: School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites,Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 434-436

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）