SYNTHESIS OF BIODEGRADABLE DEXTRAN-g-(PCL-b-PEG) BY COMBINATION OF RING-OPENING POLYMERIZATION AND CLICK CHEMISTRY

摘要：

Graft copolymers with dextran as backbone and amphiphilic PEG-b-PCL as side chains were prepared. Dextran was propargylated to form dextran-C=CH. PEG-b-PCL was synthesized by ring-opening polymerization (ROP) of ε-caprolactone using mPEG as initiator and was end-capped with azido groups to form PEG-PCL-N3. Through the click reaction between -N3 and -C=CH, the dextran backbone and the mPEG-PCL side chains were combined together via 1,2,3-triazole linkages. These polymers can self-assemble into spherical micelles with a diameter of less than 50 run, which are suitable for drug delivery research.

关键词： graft copolymer dextran self-assembly drug delivery

作者: Xiaoqing Dong Ruogu Qi Yubin Huang Xiabin Jing

作者单位: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry,Chin State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry,Chin

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 455-457

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）