BIODEGRADABLE, IN SITU FORMING POLY(ETHYLENE GLYCOL)-POLYLACTIDE HYDROGELS BY MICHAEL ADDITION CHEMISTRY

摘要：

Biodegradable, chemically crosslinked poly(ethylene glycol)-polylactide (PEG-PLA) hydrogels were synthesized by a Michael addition reaction between acrylated PEG-PLA star block copolymers and thiol-terminated multi-arm PEG. A gelation time of 1 minute was achieved when the macromonomers were crosslinked in PBS and the resulting hydrogels exhibited a storage modulus of 25 kPa. In vitro degradation experiments revealed that the hydrogels lost 30％ of polymer mass in 30 days as a result of the hydrolysis of PLA chains in the block copolymers.

关键词： PEG PLA chemically crosslinked hydrogel

作者: Sytze J.Buwalda Pieter J.Dijkstra Jan Feijen

作者单位: Department of Polymer Chemistry and Biomaterials, Faculty of Science and Technology, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, P.O.Box 217,7500 AE Enschede, The Netherlands

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 458-460

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）