PHOTO-INDUCED IN SITU FORMING HYDROGELS BASED ON COLLAGEN AND A BIOCOMPATIBLE MACROMOLECULAR PHOTOINITIATOR

摘要：

A novel cytocompatible macrophotoinitiator based on benzophenone functionalized dextran was prepared. After collagen/macrophotoinitiator mixed aqueous solutions were exposed to UVA radiation, collagen/dextran hybrid hydrogels formed in situ. The photocrosslinked hybrid gels showed higher tensile strength and elastic modulus compared to photocrosslinked collagen gels. The hybrid hydrogels supported attachment and proliferation of human mesenchymal stem cells. Due to their biocompatibility, the collagen and dextran based in situ forming hydrogels may have potential applications in drug delivery and tissue engineering.

关键词： in situ forming hydrogels macrophotoinitiator biocompatible collagen dextran

作者: Chaoliang He Fengfu Li Jae Il Ahn Malcolm Latorre May Griffith

作者单位: University of Ottawa Eye Institute, Ottawa K1H 8L6, Canada,Key Laboratory of Polymer Ecomaterials, C University of Ottawa Eye Institute, Ottawa K1H 8L6, Canada

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 473-475

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）