HEPARIN-COATED SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES AS HIGHLY EFFECTIVE MRI CONTRAST AGENT FOR CELL LABELING

摘要：

The purpose of this study was to provide highly efficient MR T2 contrast agent based on heparin-coated superparamagnetic iron oxide nanoparticles (SPIO). Two types of biocompatible magnetic agent probes were developed using unfractionated (UFH) and low-molecular-weight-heparin (LMWH), UFH-SPIO and LMWH-SPIO, respectively. The newly developed SPIOs with high signal intensity, stability, biocompatibility and magnetization can be efficiently internalized into Ins-1 cells, without changing viability and function.

关键词： superparamagnetic iron oxide nanoparticles (SPIO) cell uptake MRI

作者: Min Jin Jung Young Eun Ha Dong Yun Lee

作者单位: Department of Bioengineering, College of Engineering, Hanyang University, Seoul 133-791, Korea.Institute for Bioengineering and Biopharmaceutical Research, Hanyang University, Seoul 133-791,Korea

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 488-490

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）