CONTROLLED RELEASE OF STROMAL CELL-DERIVED FACTOR-1 FOR ENHANCED PROGENITOR RESPONSE IN ISCHEMIA

摘要：

Release of SDF-1 is integral to progenitor-mediated revascularization of ischemic muscle. SDF-1 release from microspheres was prolonged by incorporation into a collagen-based matrix, and SDF-1 microspheres were shown to have a dose-response effect on CPCs. SDF-1 microspheres were able to augment the mobilization of progenitor cells, revascularization of ischemic tissue, and restoration of perfusion in an ischemic mouse model.

关键词： collagen endothelial progenitor cell hydrogel ischemia SDF-1

作者: Drew Kuraitis Erik J Suuronen Pingchuan Zhang Kimberly McEwan Jin Zhang Daniel McKee Tanja Sofrenovic May Griffith Xudong Cao Marc Ruel

作者单位: Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa K1Y 4W7, Canada,Department Department of Chemical Engineering, University of Ottawa, Ottawa K1N 6N5, Canada Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa K1Y 4W7, Canada Department of Cellular & Molecular Medicine, University of Ottawa, Ottawa K1H 8M5, Canada

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 494-496

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）