DEVELOPMENT OF BIOCOMPATIBLE SILICONE HYROGELS WITH HIGH RESISTANCE TO PROTEIN ADSORPTION AND BACTERIAL, ADHESION

摘要：

A biocompatible silicone hydrogel comprising of carboxybetaine ester monomer, 3-methacryloxypropyltris(trimethylsiloxy)silane (TRIS), and an organic silicone macromer was prepared through photo-polymerization. High resistance to protein adsorption and bacterial adhesion is achieved after surface hydrolysis of this silicone hydrogel, while the optical and mechanical properties of the modified silicone hydrogel are still comparable with the silicone hydrogel without carboxybetaine ester groups. It is believed that this low fouling silicone hydrogel could be a candidate for preparing contact lenses with capability of sustained-release of drugs.

关键词： silicone hydrogel hydrolysis nonfouling contact lens drug delivery

作者: Weifeng Lin Juan Zhang Zhen Wang Shengfu Chen

作者单位: State Key Laboratory of Chemical Engineering and Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 511-513

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）