GENIPIN CROSSLINKED GELATIN NANOFIBERS FOR TISSUE ENGINEERING

摘要：

The objective of this study was to enhance the mechanical and thermo-mechanical properties of electrospun gelatin nanofibers, while maintaining their good bioactivity. In this work, genipin was used as crosslinker to achieve this goal. Electrospun gelatin nanofibers were crosslinked with genipin vapor at room temperature for 0 h, 6 h, 12 h, 24 h, 48 h and 72 h. The morphologies of the crosslinked nanofibrous mats were examined by scanning electron microscopy (SEM). The thermal and mechanical properties of the nanofibrous mats were examined. Bovine Serum Albumin (BSA) as a model drug was successfully incorporated into nanofibers. The release of BSA from fibrous mats crosslinked for different times was studied. The results indicated that the crosslinked nanofibrous mats have the potential of serving as tissue engineering scaffold or drug delivery vehicle.

关键词： electrospinning nanofibers crosslinking release

作者: Yan Su Xiumei Mo

作者单位: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,College of Chemistry & Chemical Engineering and Biotechnology,Donghua University, Shanghai 201620, China,Biomaterials and Tissue Engineering Laboratory, College of Chemistry & Chemical Engineering and Biotechnology,Donghua University, Shanghai 201620, China

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 523-525

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）