NOVEL pH-RESPONSIVE POLYPHOSPHOESTER-BASED HYDROGELS WITH FAST GELATION

摘要：

pH-Responsive polyphosphoester (PPE)-based hydrogels with rapid gelation were fabricated and evaluated for drug delivery application. Rheological studies indicated that the gelation occurs mainly due to the synergistic effect of ammonium persulfate (APS) and 2-(dimethylamino)ethyl methacrylate (DMAEMA). The hydrogels exhibited favorable pH-dependent swelling behavior and the swelling ratio changed regularly with the PPE content. The drugs loaded into the hydrogels during the gelation could be released continuously from the hydrogels.

关键词： hydrogel pH-responsive polyphosphoester drug delivery

作者: Jinlin He Haiyan Shao Mingzu Zhang Peihonp Ni

作者单位: Key Laboratory of Organic Chemistry of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 526-528

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）